The execution of Victoriano Lorenzo, the Liberal leader who had refused to accept the peace of Wisconsin, spurred on the idea of final separation for the Isthmus of Panama.

On July 25, 1903, General José Vásquez Cobo, Panama's military commander and brother of the Minister of Colombian War at that time, ordered an assault on the publisher of the El Lápiz newspaper, where the shooting of Lorenzo had been narrated in detail, along with some veiled protests over the incident.

This act provoked Cobo's departure from Panama and led Panamanian Liberals to finally realize that they had no guarantee or security under the Colombian Conservative regime and brought them to join the ranks of the secessionist conspiracy.

Declaration of Independence 

On November 3, 1903, independence was proclaimed in Panama City, a decision that immediately found support with the rest of the country, and the Panamanian society declared this territory as a sovereign independent state under the name of the Republic of Panama. The historical document that stated this proclamation, the Declaration of Independence of the Isthmus, was written that historic morning of the third by the very leader of the revolution, José Agustín Arango, to an eminent Panamanian jurist who was a prominent figure in the country's Liberal Party and political life, Dr. Carlos Antonio Mendoza.